Table 5.

Eicosanoids and oxidation products of polyunsaturated fatty acids concentration in uterine luminal fluid from Control (Con) and Pregnant (Preg) cows.

Metabolite	Group		P value	FDR significancea	Log2 Fold-changeb
	Con (n = 8)	Preg (n = 10)
Arachidonic acid	12.95 ± 1.81	18.27 ± 0.90	0.18	n.s.	0.50
Docosahexaenoic acid (DHA)	2.58 ± 0.25	3.47 ± 0.11	0.06	n.s.	0.43
13(S)-HODEc	0.14 ± 0.02	0.06 ± 0.004	0.009	*	−1.12
12(S)-HETEc	0.06 ± 0.006	0.15 ± 0.003	0.0001	**	1.34
15(S)-HETEc	0.013 ± 0.005	0.038 ± 0.003	0.02	*	1.51
6-keto-Prostaglandin F1alpha (PGI2)d	0.08 ± 0.01	0.09 ± 0.002	0.74	n.s.	0.06
Prostaglandin F2alpha (PGF2α)d	0.07 ± 0.004	0.09 ± 0.001	0.04	n.s.	0.24

Values are expressed as nmol/cm² of endometrial area; mean ± SEM. Biochemical name, abbreviation and PubChem CID of metabolites are listed in Supplemental Table S1 by class.

Metabolites in bold were different between Con and Preg group by ANOVA followed by FDR correction.

^aStatistical analyses were carried out by one-way ANOVA followed by FDR correction for multiple comparisons. Magnitude of effect is indicated by: **P ≤ 0.01; *P ≤ 0.05; n.s. P > 0.05.

^bData are represented as fold-change of the metabolite concentration between Preg and Con groups.

^cLipoxygenase metabolite products.

^dCyclooxygenase metabolite products.