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. 2019 Jun 7;10:2524. doi: 10.1038/s41467-019-10513-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Visualization of degradation at the level of individual transcripts and proteins. a Heatmap (bottom) of mKS matrix illustrating the degree of degradation of each individual transcript (rows), with samples (columns) ordered by mRINs. The bar plot (top) displays each sample’s mRIN (median centered). Samples with significant mRNA degradation are highlighted in yellow in the bar plot (n = 68). b Similar to a, but for iPIS matrix with samples ordered by the PIN values. Four samples with significant protein degradation are highlighted in yellow in the bar plot (n = 68)