Fig. 5.

Detailed mRNA and protein degradation characteristics. a Hierarchical clustering of all proteins quantified in the sample cohort. b Hierarchical clustering of quantified proteins without degradation-prone proteins. c The reproducibility of fully tryptic peptides was higher than that of semi-tryptic peptides, as demonstrated in the box plot. d A stronger covariation of fully tryptic peptides across 68 samples with other peptides generated from the same protein was observed, compared with that of semi-tryptic peptides. The line within the box represents the median, the borders of the box represent the interquartile range and the whiskers represent smallest and largest values no more than 1.5 times the interquartile range; n = 27,685 for fully tryptic peptides, n = 2133 for semi-tryptic peptides