Figure 6.

The effects of exosomes on BLM‐induced lung remodelling in the absence or presence of serelaxin (RLX). Representative images of TSLP (a), TGF‐β1 (c), and α‐SMA (e)‐stained lung sections from mice subjected to BLM‐induced pulmonary fibrosis and the various treatment investigated demonstrate the extent of airway epithelial damage (a), interstitial TGF‐β1 expression levels (c), and interstitial myofibroblast accumulation (e) within the lung. Scale bar = 50 μm in each case. Also shown is the mean ± SEM BLM‐induced number of TSLP‐stained cells per 100‐μm BM length (b); relative interstitial TGF‐β1 staining/field (d); and % interstitial myofibroblast staining/field (f) from 5 to 6 fields/mouse section; n = 7 animals/group. *P < 0.05 versus SAL‐treated uninjured control group; ^# P < 0.05 versus BLM‐treated injured group; ^¶ P < 0.05 versus BLM + 5‐μg EXO‐treated group; ^† P < 0.05 versus BLM + 25‐μg EXO‐treated group; ⁺ P < 0.05 versus BLM + AEC + RLX‐treated group; ^¥ P < 0.05 versus BLM + Pirfenidone‐treated group