Figure 7.
DEA‐NO‐induced activation of Kv current, hyperpolarization, and relaxation is not affected by Kv1.5 channel inhibition. (a) Average values of the Kv currents obtained after 4‐s depolarization pulses from −60 to +20 mV in PASMCs perfused with the Kv1.5 channel inhibitor DPO‐1 (1 μM, n = 10 from seven animals) in the absence and in the presence of DEA‐NO (10 μM). (b) Average values of DEA‐NO‐sensitive currents in the presence of DPO‐1 obtained by subtracting the current in the presence and in the absence of DEA‐NO. (c) Mean values of the changes in the membrane potential induced by DEA‐NO in the absence and in the presence of DPO‐1 (n = 8–9 from five to seven animals). (d) Averaged data of the concentration‐dependent relaxant responses induced by DEA‐NO (0.1–30 μM) in the absence (n = 11) or the presence of DPO‐1 (n = 6). *P < 0.05 versus DPO‐1 (Student's paired t test). Results are means ± SEM