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. 2019 Jun 7;19:551. doi: 10.1186/s12885-019-5765-3

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Three BRCA1 LGRs detected in the HBOC cohort. MLPA result for BRCA1 LGRs in bar chart format generated by Coffalyser software v.9. BRCA1 exons and intra normalized ratio are given on the X axis and Y axis, respectively. Exons having reduced or increased peak ratio are denoted by red or blue dot, respectively. a MLPA result for BRCA1 wildtype. b exon5-7dup. c exon13-14dup. d exon1-22del. e exon5-7dup was confirmed by LR-PCR