Table 3.
Neuropathologic characteristics by resistance and resilience status
| Pathology (mean+/− SD) |
Resistant (n = 14) |
AD Dementia Matched to Resistant (n = 14) |
p value | Resilient (n = 7) |
AD Dementia Matched to Resilient (n = 7) |
p value |
|---|---|---|---|---|---|---|
| Brain Weight (grams) | 1228 (75) | 1115 (84) | 0.001 | 1223 (151) | 1120 (205) | 1.128 |
| Thal Phase | 0.64 (0.50) | 4.57 (0.51) | ND | 4.33 (0.52) | 4.86 (0.38) | ND |
| Braak Stage | 3.36 (0.74) | 5.79 (0.43) | ND | 5.86 (0.38) | 5.86 (0.38) | ND |
| CERAD score | 0.07 (0.27) | 3.00 (0.0) | ND | 3.00 (0.0) | 3.00 (0.0) | ND |
| Atherosclerosis | 1.93 (0.62) | 2.29 (0.50) | 0.097 | 1.86 (1.10) | 1.57 (0.53) | 0.421 |
| Arteriolosclerosis | 2.00 (0.68) | 2.57 (0.51) | 0.031 | 2.14 (0.38) | 2.29 (0.76) | 0.655 |
| Macroinfarcts | 0.50 (0.85) | 0.57 (0.76) | 0.895 | 0 (0) | 0.86 (1.07) | 0.048 |
| Microinfarcts | 1.07 (1.27) | 1.50 (1.23) | 0.356 | 0.57 (1.13) | 1.14 (1.07) | 0.389 |
| CAA severity (OC) | 0.50 (0.85) | 1.36 (0.84) | 0.015 | 1.86 (1.35) | 1.42 (0.79) | 0.252 |
| Lewy body distribution | 1.00 (1.57) | 1.50 (1.83) | 0.388 | 0 (0) | 0.57 (1.51) | 0.317 |
| LATE-NC | 0.21 (0.58) | 2.40 (0.94) | 0.0009 | 0.43 (1.13) | 1.86 (0.90) | 0.047 |
Wilcoxon matched-pairs signed-ranks test; ND, Not Done; LATE-NC, limbic-predominant age-related TDP-43 encephalopathy neuropathologic change. Bold values indicate statistical significance