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. 2019 Jun 7;7:148. doi: 10.1186/s40425-019-0619-8

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — High CD8+ TIL abundance associates with decreased recurrence in MIUC

The relative immune cell scoring for CD8+ T-cells were dichotomized as high and low to determine its impact on bladder cancer outcome. Low CD8+ TIL abundance significantly associated with earlier disease recurrence (a) in a subset of 318 patients with available recurrence data. The association between CD8+ T-cell abundance and overall survival (b) was also significant. Basal squamous tumors showed two distinct groups of high and low CD8+ T-cell abundance with a significant association with disease recurrence within (c) and a trend for significance in predicting shorter overall survival for this MIUC subtype (d)