Fig. 5.

DDR mutations associate with immune regulatory gene expression in MIUC. Tumors with DDR mutations show differences in expression patterns of immunoregulatory genes. The effect of DDR biallelic and monoallelic inactivation in the expression of immune-regulatory genes are shown in (a) and (b), respectively. There is a gradual decrease in the average expression levels of tumors harboring DDR mutations. In contrast, wild-type tumors exhibit high levels of expression across tumors (d Additional file 1: Fig. S6). The average z-score was obtained for each investigated DDR gene (averaged z-score by row). Mutations in DDR genes in the TCGA MIUC were not mutually exclusive with the presence of concurrent mutations