Table 3.

A comparison of the times to find routes

Example route	No. of routes	Max. route length	Time (no OSM)	Time (with OSM)
L-Tryptophan →indoxyl sulfate	3	9	25 s	161 s
L-carnitine →TMAO	3	7	9 s	115 s
SAM →L-homoserine lactone	4	4	9 s	9 s

Each example route search was run without or with organism switching minimization (OSW). OSW is turned off when the “switching organisms cost” parameter is set to zero. This parameter was set to 30 for the runs with OSW. Because the run time can be very sensitive regarding the “maximum route length” parameter, these settings are also shown in the table. The data was collected with MORS running on a single CPU core of type Intel(R) Xeon(R) CPU E5-2690 0 @ 2.90 GHz.