Fig. 1.

H. cordata and 2-undecanone prevent tumorigenesis in a B[a]P-induced lung cancer mouse model. a A/J mice were intraperitoneally injected with B[a]P (100 mg/kg) in the 1st week, orally treated with H.cordata (25 or 50 g/kg) or 2-undecanone (100 or 200 mg/kg) five times a week from the 3rd to the 38th week, and finally sacrificed after treatment. b Average body weight curves for the A/J mice (n = 8). c Photos of pulmonary nodules dissected from the A/J mice (scale bar: 3 mm). All photos were obtained using a stereoscopic microscope. Tumor numbers and tumor inhibition rates were analyzed. The data represent the mean ± SD (n = 8). d Organ indexes for A/J mouse hearts, livers, spleens, kidneys and thymuses. ^*p < 0.05 and ^**p < 0.01 compared with the control group (given B[a]P); ^#p < 0.05 and ^##p < 0.01 compared with the control group (given B[a]P + oil)