Table 2:
Minimum inhibitory concentration (MIC, in µM) of the four most potent aryl isonitrile compounds and control antibiotics against methicillin-sensitive (MSSA), methicillin-resistant (MRSA), linezolid-resistant (LRSA), and vancomycin-resistant S. aureus (VRSA).
| Compound Name | S. aureus NRS107 (MSSA) | MRSA NRS119 (LRSA) | MRSA NRS384 (USA300) | MRSA NRS385 (USA500) | VRS10 (VRSA) | VRS11a (VRSA) |
|---|---|---|---|---|---|---|
| 7 | 2 | 1 | 1 | 4 | 2 | 4 |
| 13 | N.D.1 | 4 | 4 | N.D. | 32 | N.D. |
| 18 | 16 | 4 | 4 | 16 | 8 | 16 |
| 19 | 4 | 1 | 2 | 8 | 8 | 8 |
| Linezolid | 2 | 32 | 2 | 4 | 2 | 2 |
| Vancomycin | 1 | 1 | 1 | 1 | >64 | >64 |
1
N.D. = Not determined