. Author manuscript; available in PMC: 2020 May 1.

Published in final edited form as: Bioorg Med Chem. 2019 Mar 19;27(9):1845–1854. doi: 10.1016/j.bmc.2019.03.034

Table 4:

Minimum inhibitory concentration (MIC, in µM) of 19 and control antibiotics against Gram-negative bacterial pathogens in the presence of a subinhibitory concentration of colistin (COL).

Test Agent	Bacterial Strain
Test Agent	A. baumannii BAA-1605	E. cloacae BAA-1134	K. pneumoniae ATCC BAA-1705	P. aeruginosa ATCC 15442	E. coli BW25113		E. coli JW25113 (ΔtolC)
					(−COL¹)	(+COL)	(−COL)	(+COL)
19	16	4	>64	>64	>64	>64	>64	>64
Erythromycin	4	1	16	4	64	1	2	0.50
Linezolid	>64	16	>64	>64	>64	>64	16	16

No colistin added to the media