Table 4.

Gene sets enriched in the samples of primary HCC in the high expression of TRMT6 group.

Outcome		TRMT6 expression (high vs. low)		TRMT6 expression (continuous variable)
		HR (95% CI)	P	HR (95% CI)	P
RFS	Univariable	1.437 (1.051, 1.965)	0.023	1.482 (1.087, 2.022)	0.013
	Multivariablea	1.871 (1.204, 2.905)	0.005	1.537 (0.960, 2.461)	0.073
	Multivariableb	2.226 (1.313, 3.774)	0.003	1.691 (0.970, 2.949)	0.064
OS	Univariable	1.539 (1.086, 2.180)	0.015	1.862 (1.327, 2.614)	<0.001
	Multivariablec	2.176 (1.234, 3.836)	0.007	2.730 (1.531, 4.869)	<0.001
	Multivariableb	3.051 (1.553, 5.996)	0.001	3.279 (1.762, 6.099)	<0.001

^aModel was adjusted for tumor stage based on selection of variables with p<0.1 in univariable analysis;

^bModel was adjusted for all potential confounders presented in Table 1;

^cModel was adjusted for age and tumor stage based on selection of variables with p<0.1 in univariable analysis.