Figure 4.

Effect of compressive force on mineral resorption activity. Cells on the calcium phosphate-coated plate were continuously stimulated with, 0.3, 0.6, or 1.1 g/cm² compressive force in the presence of 5 ng of RANKL for 4 days. (A) Resorption pits were observed by light microscopy. Scale bar=100 μm. (B) Calcium phosphate released from the plate was quantified by fluorescence intensity. Bars indicate the means ± standard deviation of four independent experiments. * P<0.05, *** P<0.01 (vs. 0.3 g/cm²), ^## P<0.01 (0.6 vs. 1.1 g/cm²).