| LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing |
Kabeya, Yukiko |
Embo Journal (10.557) |
2000 |
4,118 |
The authors demonstrate that the rat microtubule-associated protein 1 light chain 3 (LC3), a homologue of Apg8p essential for autophagy in yeast, is associated with the autophagosome membranes after processing. |
| Autophagy in the pathogenesis of disease |
Levine, Beth |
Cell (31.398) |
2008 |
3,672 |
This review summarizes recent advances in understanding the physiological functions of autophagy and its possible roles in the causation and prevention of human diseases. |
| Autophagy fights disease through cellular self-digestion |
Mizushima, Noboru |
Nature (41.577) |
2008 |
3,549 |
This review describes the main mechanisms of autophagy and its role in disease. |
| Development by self-digestion: Molecular mechanisms and biological functions of autophagy |
Mizushima, Noboru |
Developmental Cell (9.616) |
2004 |
2,460 |
In this review, the authors focus on macroautophagy, an evolutionarily served process that occurs in virtually all eukaryotic cells, ranging from yeast to mammals. |
| Methods in Mammalian Autophagy Research |
Mizushima, Noboru |
Cell (31.398) |
2010 |
2,287 |
In this Primer, the authors discuss methods to monitor autophagy and to modulate autophagic activity, with a primary focus on mammalian macroautophagy. |
| Autophagy as a regulated pathway of cellular degradation |
Klionsky, Daniel J |
Science (41.058) |
2000 |
2,230 |
This review limits the discussion to macroautophagy, the major inducible pathway for general turnover of cytoplasmic components. |
| Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice |
Hara, Taichi |
Nature (41.577) |
2006 |
2,220 |
In this article, the authors report that loss of autophagy causes neurodegeneration even in the absence of any diseaseassociated mutant proteins. |
| AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1 |
Kim, Joungmok |
Nature Cell Biology (19.064) |
2011 |
2,212 |
This article reveals a signalling mechanism for Ulk1 regulation and autophagy induction in response to nutrient signalling. |
| Guidelines for the use and interpretation of assays for monitoring autophagy |
Klionsky, Daniel J |
Autophagy (11.1) |
2012 |
2,177 |
A set of guidelines are presented for the selection and interpretation of methods for use by investigators, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. |
| Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy |
Pattingre, Sophie |
Cell (31.398) |
2005 |
2,161 |
This article shows that wild-type Bcl-2 antiapoptotic proteins, but not Beclin 1 binding defective mutants of Bcl-2, inhibit Beclin 1-dependent autophagy in yeast and mammalian cells and that cardiac Bcl-2 transgenic expression inhibits autophagy in mouse heart muscle. |
