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. 2019 Jun 4;12:4391–4402. doi: 10.2147/OTT.S201052

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© 2019 Deng et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

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Overexpression of METTL3 inhibited CRC growth and migration. (A) Overexpression of METTL3 in KM12 and HCT8 cells was validated by qRT-PCR (*P<0.05). (B) Overexpression of METTL3 in KM12 and HCT8 cells was validated by Western blot assay (*P<0.05). (C) Overexpression of METTL3 inhibited cellular proliferation. (D) Overexpression of METTL3 was clearly associated with decreased number of colony formation. (E) Overexpression of METTL3 inhibited cell migration capacity. (F) Overexpression of METTL3 inhibited cell invasion capacity. *P<0.05. All experiments were independently set up three times.

Abbreviations: CRC, colorectal cancer; METTL3, methyltransferase 3.