Table 2.
Multivariate analysis of overall survival in 181 CRC patients
| Variable | HR | Univariate analysis | P | HR | Multivariate analysis | P |
|---|---|---|---|---|---|---|
| 95% CI | 95% CI | |||||
| Age | ||||||
| ≥60 vs. <60 | 1.185 | 0.756–1.856 | 0.459 | |||
| Gender | ||||||
| Male vs. female | 1.036 | 0.681–1.577 | 0.867 | |||
| Tumor side | ||||||
| Right vs. left | 0.898 | 0.587–1.373 | 0.619 | 0.599 | 0.378–0.948 | 0.029 |
| Tumor size | ||||||
| >15 vs. <15 | 1.817 | 1.187–2.781 | 0.006 | 1.744 | 1.121–2.713 | 0.014 |
| Metastasis | ||||||
| Yes vs. no | 3.492 | 1.591–7.665 | 0.002 | |||
| Clinical stage | ||||||
| III–IV vs. I–II | 2.977 | 1.781–4.978 | 0.000 | 2.836 | 1.661–4.842 | 0.000 |
| Tumor stage | ||||||
| T2–T4 vs. T1 | 3.721 | 1.176–11.774 | 0.025 | 3.315 | 1.039–10.575 | 0.043 |
| METTL3 expression | ||||||
| Negative vs. positive | 2.024 | 1.106–3.529 | 0.013 | 1.908 | 1.087–3.347 | 0.024 |
Notes: Bold: P<0.05, P values were two-tailed and based on Pearson Chi-square test.
Abbreviations: CRC, colorectal cancer; METTL3, methyltransferase 3.