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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Neuroscience. 2019 Mar 28;408:68–80. doi: 10.1016/j.neuroscience.2019.03.036

Figure 6. Audiogenic epilepsy and sudden unexpected death in epilepsy (SUDEP) in TSP2−/− and double TSP1/2−/− mutant mice.

Figure 6.

Data from videotape collected during noise exposure of wild type, TSP single, and TSP double mutant mice. (A) Percentage of animals per genotype that had audiogenic seizures and SUDEP after exposure to octave band noise. 70% of TSP2−/− and 80% and TSP1/2−/− mice exhibited audiogenic seizures. About 38% of the mutant mice showed SUDEP. While WT mice had a 8% risk of audiogenic seizure, none of the TSP1−/− mice tested (n=18) experienced an audiogenic seizure during noise exposure. (B) Percentage of animals per genotype that manifested seizure at a specific frequency. 80% of TSP2−/− mice had seizure at 16kHZ but none at 8kHz. 78% of TSP1/2−/− mice exhibited seizures at 8kHz and 93% at 16kHZ.