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. Author manuscript; available in PMC: 2020 Jan 15.
Published in final edited form as: Adv Drug Deliv Rev. 2018 Dec 8;139:51–70. doi: 10.1016/j.addr.2018.12.006

Fig. 12.

Fig. 12.

Glucose-responsive matrix-loaded MN for controllable insulin delivery. A) Schematic of the glucose-responsive insulin delivery system using H2O2 responsive PVA-TSPBA gel. B) Fluorescence images of rhodamine B-labeled insulin-loaded MN arrays with FITC-labeled HA base (left) and a cross-section of MN containing rhodamine B-labeled CAT shell and FITC-labeled insulin core (right). Scale bar: 300 μm. D) In vitro release profile of insulin from gels in PBS 7.4 in he presence of GOx (0.2 mg/mL). n = 3 (left); Blood glucose levels of diabetic mice treated with different kinds of MN array patches, n = 5 (middle); Blood glucose levels of diabetic mice treated with multiple MN array patches. The administration of MN-CAT is indicated by blue arrows. MNs were removed as indicated by red arrows, n = 5 (right). Adapted with permission from Ref [243].