Table 4.

Permeation Parameters of (A1–A5) lamotrigine matrix patches

Permeation parameters	A1	A2	A3	A4	A5
Flux (mg/cm2h)	0.258	0.575	0.916	0.409	0.416
Intercept	− 0.054	− 0.188	− 0.044	− 0.193	− 0.005
R 2	0.9982	0.9935	0.9958	0.9987	0.9973
Permeation coefficient (P) (cm/h)	0.009	0.019	0.031	0.014	0.014
Time lag (L) (min)	12.6	19.8	3	1.41	0.6
Diffusion coefficient (DC) (cm2/h)	2.35E−04	1.51E−04	1.02E−03	1.05E−04	3.78E−03
Enhancement ratio (ER)	1.00	2.22	3.55	1.58	1.61
F D	0.252	0.490	0.713	0.292	0.409
F s	0.748	0.510	0.287	0.708	0.591
Best-fit equation	Qt = 0.258t-0.054	Qt = 0.575t-0.188	Qt = 0.916t-0.044	Qt = 0.409t-0.193	Qt = 0.416t-0.005