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. Author manuscript; available in PMC: 2020 Mar 5.
Published in final edited form as: Chem Commun (Camb). 2019 Mar 5;55(20):2976–2979. doi: 10.1039/c9cc00641a

Table 3.

Substrate Scope

graphic file with name nihms-1021710-t0006.jpg
Entry R (#) RCY (%)#
1 H (118F) 21 ± 5 (n=7)
2 Ac (218F) 13 ± 3 (n=5)
3 CN (318F) 20 ± 5 (n=4)
4 F (418F) 16 ± 2 (n=7)
5 I (518F) 14 ± 1 (n=4)
6 Br (618F) 12 ± 3 (n=5)
7 Cl (718F) 11 ± 2 (n=4)
8 Me (818F) 15 ± 2 (n=5)
9 Ph (918F) 14 ± 2 (n=5)
10 MeO (1018F) 0 (n=7)
a

General conditions: aliquots of a prestirred stock solution containing Ag[18F]F (92.5–129.5 MBq) and PhI(OAc)2 (2 equiv) in CH2Cl2 (200 μL) were added to vials containing substrate (0.042 mmol) and Pd2(dba)3 (10 mol %) in CH2Cl2 (550 μL). Reactions were heated at 145 oC for 30 min, RCC was determined by radio-TLC.