Table 5.

Multiple linear regression: Effect of vitamin D metabolites on muscle-related outcomes

		Δ25(OH)D (N=302)		Δ1,25(OH)2D (N=302)		ΔiPTH (N=302)
ΔMuscle Outcomes	N	Beta	p-value	Beta	p-value	Beta	p-value
Fat-Free Soft Tissue (kg)	300	−0.034	0.562	−0.003	0.954	0.112	0.054
Handgrip Strength (kg)	285	0.028	0.653	0.074	0.232	0.046	0.464
Forearm MCSA (mm2)	299	0.025	0.678	0.102	0.086	0.097	0.101
Forearm MD (mg/cm3)	299	0.049	0.415	−0.029	0.629	0.002	0.971
Forearm IMAT (mm2)	265	−0.053	0.413	0.093	0.147	0.135	0.035
Calf MCSA (mm2)	296	0.015	0.811	0.085	0.158	0.180	0.003
Calf MD (mg/cm3)	296	−0.038	0.526	0.025	0.677	−0.101	0.090
Calf IMAT (mm2)	280	0.065	0.323	0.024	0.707	0.135	0.038

^1.Δ = Post-Baseline values

^2.Multiple linear regression controlling for race, sex, age, and latitude; Change in serum and muscle-related outcomes (post - baseline). Statistically significant if P ≤ 0.05 and in bold font. Beta coefficient displays strength or influence of the independent variable over the dependent variable.

^3.MCSA, muscle cross-sectional area; MD, muscle density; IMAT, intermuscular adipose tissue