Table 2.
Metabolites significantly associated with muscle composition (NDM/LDM).
| β ± SE | p-Value | q-Value | |
|---|---|---|---|
| Mannitol | − 0.0 ± 0.0 | 1.0E − 05 | 0.0001 |
| 2-Hydroxyisobutyrate | − 0.1 ± 0.0 | 5.6E − 05 | 0.0006 |
| Urea | − 0.1 ± 0.0 | 0.0008 | 0.005 |
| Butyrylcarnitine | − 0.1 ± 0.0 | 0.0009 | 0.006 |
| Pseudouridine | − 0.1 ± 0.0 | 0.001 | 0.008 |
| N-acetylthreonine | − 0.1 ± 0.0 | 0.001 | 0.008 |
| Tiglyl carnitine | − 0.1 ± 0.0 | 0.002 | 0.01 |
| Erythronate | − 0.1 ± 0.1 | 0.002 | 0.01 |
| 4-Acetamidobutanoate | − 0.1 ± 0.0 | 0.002 | 0.01 |
| Glutamine | 0.2 ± 0.1 | 0.003 | 0.01 |
| C-glycosyltryptophan | − 0.1 ± 0.0 | 0.003 | 0.02 |
| Serine | 0.1 ± 0.0 | 0.004 | 0.02 |
| Erythritol | − 0.1 ± 0.0 | 0.004 | 0.02 |
| Glutaroyl carnitine | − 0.1 ± 0.0 | 0.007 | 0.03 |
| Glycoursodeoxycholate | 0.0 ± 0.0 | 0.009 | 0.04 |
| Phenylacetylglutamine | − 0.0 ± 0.0 | 0.01 | 0.04 |
| Dimethylglycine | − 0.1 ± 0.0 | 0.01 | 0.04 |
| 5α-Androstan-3β,17beta-diol disulfate | − 0.0 ± 0.0 | 0.01 | 0.04 |
| 2-Methylbutyroylcarnitine | − 0.1 ± 0.0 | 0.01 | 0.04 |
| Indolelactate | − 0.1 ± 0.0 | 0.01 | 0.04 |
| Alanine | 0.1 ± 0.0 | 0.01 | 0.05 |
| N-acetylalanine | − 0.1 ± 0.1 | 0.01 | 0.05 |
| Methylglutarylcarnitine | − 0.0 ± 0.0 | 0.01 | 0.05 |
| Octanoylcarnitine | − 0.0 ± 0.0 | 0.01 | 0.05 |
| Myo-inositol | − 0.1 ± 0.0 | 0.01 | 0.05 |
| Arabitol | − 0.1 ± 0.0 | 0.01 | 0.05 |
| Biliverdin | 0.0 ± 0.0 | 0.01 | 0.05 |
| Arabonate | − 0.0 ± 0.0 | 0.02 | 0.05 |
| Isobutrylcarnitine | − 0.0 ± 0.0 | 0.02 | 0.05 |
| Decanoylcarnitine | − 0.0 ± 0.0 | 0.02 | 0.06 |
| N-formylmethionine | − 0.1 ± 0.0 | 0.02 | 0.06 |
| Glycine | 0.1 ± 0.0 | 0.02 | 0.07 |
| Acetylcarnitine | − 0.1 ± 0.0 | 0.02 | 0.07 |
| Phenol sulfate | − 0.0 ± 0.0 | 0.02 | 0.07 |
| N1-methyl-2-pyridone-5-carboxamide | − 0.1 ± 0.0 | 0.02 | 0.07 |
| Glucuronate | − 0.0 ± 0.0 | 0.02 | 0.07 |
| Trans-4-hydroxyproline | − 0.1 ± 0.0 | 0.02 | 0.07 |
| Laurylcarnitine | − 0.0 ± 0.0 | 0.03 | 0.07 |
| N-acetylmethionine | − 0.1 ± 0.0 | 0.03 | 0.07 |
| Xanthine | 0.0 ± 0.0 | 0.03 | 0.07 |
| Deoxycarnitine | 0.1 ± 0.1 | 0.03 | 0.07 |
| Cis-4-decenoyl carnitine | − 0.0 ± 0.0 | 0.03 | 0.08 |
| Hexanoylcarnitine | − 0.0 ± 0.0 | 0.03 | 0.08 |
| Ergothioneine | 0.0 ± 0.0 | 0.03 | 0.08 |
| Symmetric dimethylarginine | − 0.1 ± 0.0 | 0.03 | 0.08 |
| Cortisone | 0.1 ± 0.0 | 0.03 | 0.08 |
| Asparagine | 0.1 ± 0.0 | 0.03 | 0.09 |
| N6-acetyllysine | − 0.1 ± 0.0 | 0.03 | 0.09 |
| Tetradecanedioate | − 0.0 ± 0.0 | 0.03 | 0.09 |
| 7-Methylguanine | 0.1 ± 0.0 | 0.04 | 0.09 |
| Trans-urocanate | 0.1 ± 0.0 | 0.04 | 0.09 |
| 10-Undecanoate | 0.1 ± 0.0 | 0.04 | 0.09 |
| 1,5-Anhydroglucitol | − 0.0 ± 0.0 | 0.04 | 0.09 |
| Epiandrosterone sulfate | − 0.0 ± 0.0 | 0.04 | 0.09 |
| 7-α-Hydroxy-3-oxo-4-cholestenoate | 0.1 ± 0.0 | 0.04 | 0.10 |
| Threitol | − 0.0 ± 0.0 | 0.05 | 0.10 |
| 1-Methylurate | − 0.0 ± 0.0 | 0.05 | 0.10 |
| Androsterone sulfate | − 0.0 ± 0.0 | 0.05 | 0.10 |
| N-acetylserine | − 0.1 ± 0.0 | 0.05 | 0.10 |
| N1-methyladenosine | − 0.1 ± 0.1 | 0.05 | 0.10 |
Sex, age and whole body fat mass-adjusted associations between serum metabolites with NDM/LDM are shown with parameter estimates and standard errors (β ± SE), in order of significance (p-value), and with q-values.