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Dose dependencies of YKS for the effect on bone cancer pain. Mice were administered p.o. with the indicated doses of YKS once daily for 7 days or with a single p.o. administration of 10 mg YKS 1 h before assessment on day 7. Each column represents the R/L ratio of weight bearing (a) and surface resting (b). The values shown are the mean ± SD (n = 6). One-way repeated ANOVA was applied for statistical analysis. ∗P < 0.05 compared to 0 mg (saline). †P < 0.05 compared to control.
