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. 2019 May 26;2019:2956920. doi: 10.1155/2019/2956920

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Copyright © 2019 Kenta Nakao et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Time courses for the effect of i.t. or i.p. injection of saline, MMP-2 inhibitor or MMP-9 inhibitor on bone cancer pain. Bone cancer model mice were i.p injected with 50 μg of MMP-2 or MMP-9 inhibitor (a, b) or i.t. injected with 0.5 μg of MMP-2 or MMP-9 inhibitor (c, d); and weight bearing (a, c) and surface resting (b, d) were measured as described in the legend for Figure 2. The values shown are the mean ± SD (n=6). Student's t-test was applied for statistical analysis. ∗P < 0.05 compared to saline.