Table 1.

Patient data and characteristics.

	Mahmoud et al. [7]		Andrä et al. [8]		González-González et al. [9]		Vitzthum et al. [10]		Tejani et al. [6]		Penel et al. [11]		Sidappa and Krishnamurthy [12]		Park et al. [13]		Total
Country	USA		Germany		Mexico		USA		USA		France		India		Korea		N	%
Years	2004–2013		2003–2012		2004–2009		1998–2012		1999–2009		1997–2002		1996–2005		1995–2012
	N	%	N	%	N	%	N	%	N	%	N	%	N	%	N	%
Cases	788		26		51		48		30		28		27		122		1120
Male	539	68	18	69	31	61	34	71	20	67	15	54	17	63	65	53	739	66
Median age	63		64		43.1		68.5		50		45.7		35		46		—
<50	181	23a	—		34	67	—		12	40	11	39	—		—		238	27
>50	607	77	—		17	33b	—		18	60	17	61b	—		—		659	73
Tumour size
<5 cm	443	56	—		15	29c	33	69c	13	43	—		17	63	86	70c	607	57
>5 cm	345	44d	—		36	71	15	31	11	37	—		10	37	36	30	453	43
Mean tumour size (cm)	4.5e		4.6e		—		—		—		2.7		4.8				—
Grade (FNCLCC)
High/G3	788	100	17	65	30	59	28	58f	23	77	16	57	21	78g	22	18	945	84
Intermediate/G2	0		8	31	10	20	0		3	10	8	29	0		53	43	82	7
Low/G1	0		1	4	11	22	6	13	2	7	2	7	6	22	30	25	58	5
Unspecified/unknown	0		0		0		14	29	2	7	2	7	0		17	14	35	3
T stage
0	—		—		—		—		—		—		—		—		—
1	—		14	54	13	25	—		12	40	—		—		—		39	23
2	—		12	46	38	75	—		18	60	—		—		—		68	40
3	—		—		—		—		—		—		—		—		—
4	—		—		—		—		—		—		—		—		—
Surgical margins†
R0	497	63	10	39	35	69	41	85	17	57	—		20	74	76	62	696	60
R1	111	14	6	23	4	8	—		7	23	—		6	22h	20	16	154	13
R2	180	23	5	19	13	25	3	6	—		—		—		7	6	208	18
Unspecified/unknown	—		5	19	—		4	8	—		—		—		—		9	1
5-year OS	—			82	—			83		46	—		68		75		—
5-year DFS	—		—		—			63		35	—		65		—		—
Median follow-up (months)	45		39		23.8		57.6		—		27		59		72		—

^a≤50, ^b≥50, ^c≤5, ^d≥5, ^emedian, ^fgrade 2 + 3, ^ggrading system not specified in the article, and ^hR1 + R2. ^†R0 = negative surgical margins/clear margins, R1 = microscopic positive surgical margins/microscopic involved margins, and R2 = macroscopic positive margins/macroscopic involved margins.