Table 1.
Gene functions for some of the positively selected genes identified in T. spiralis.
| Gene function | GenBank No. | Gene family |
|---|---|---|
| Xenobiotic metabolism | EFV51745 | oxidoreductase, short chain dehydrogenase/reductase family |
| EFV54917 | dimethylaniline monooxygenase [N-oxide-forming] 4 | |
| EFV50316 | cytochrome P450 4V2 | |
| EFV50200 | heparan sulfate glucosamine 3-O-sulfotransferase 3A1 | |
| EFV57943 | protein-tyrosine sulfotransferase A | |
| EFV50642 | putative ABC transporter, ATP-binding protein | |
| EFV53848 | putative ABC transporter, ATP-binding protein | |
| EFV54367 | putative ABC transporter, ATP-binding protein | |
| EFV56075 | putative ABC transporter, ATP-binding protein | |
| EFV48926 | putative ABC transporter, ATP-binding protein, partial | |
|
| ||
| DNA repair proteins | EFV4940 | DNA mismatch repair protein Msh6 |
| EFV57314 | DNA repair protein RAD51 | |
| EFV55613 | DNA repair protein Rad4 | |
| EFV55989 | DNA cross-link repair 1A protein | |
| EFV62248 | DNA excision repair protein haywire | |
|
| ||
| Penetration/digestion | EFV60084 | lysosomal aspartic protease |
| EFV52155 | ATP-dependent Clp protease, proteolytic subunit ClpP | |
| EFV51535 | putative ATP-dependent Clp protease, ATP-binding subunit ClpX | |
| EFV53966 | cysteine protease ATG4B | |
| EFV54564 | putative ATP-dependent protease La | |
|
| ||
| Muscle cell transformation | EFV53122 | putative helix-loop-helix DNA-binding domain protein |
| EFV57695 | putative helix-loop-helix DNA-binding domain protein | |
| EFV61981 | putative helix-loop-helix DNA-binding domain protein | |
| EFV55197 | cell differentiation protein RCD1-like protein | |
|
| ||
| Cell cycle arrest | EFV56859 | G2/mitotic-specific cyclin-B3 |
| EFV56912 | cyclin-dependent kinase inhibitor 2B-related protein | |
|
| ||
| Antiapoptotic and immunomodulatory activities | EFV60199 | translationally-controlled tumor protein-like protein |
|
| ||
| Surface proteins used for creating new parasite-specific morphological structures | ||
|
| ||
| Cadherin | EFV54837 | putative cadherin domain protein, partial |
| EFV54875 | putative cadherin domain protein, partial | |
| EFV57941 | putative cadherin domain protein | |
|
| ||
| Cuticle collagen | EFV60533 | cuticle collagen 34 protein |
| EFV60602 | cuticle collagen 3 | |
| EFV52694 | cuticle collagen rol-6 | |
| EFV52706 | cuticle collagen dpy-7 | |
| EFV52845 | cuticle collagen dpy-13 | |
|
| ||
| Metabolic Pathways | ||
|
| ||
| β-oxidation pathway | EFV50357 | putative 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain protein |
| EFV58588 | lonCoA ligase 5 | |
|
| ||
| Glycolysis | EFV55075 | putative hexokinase HKDC1 |
| EFV52822 | enolase | |
| EFV54356 | L-lactate dehydrogenase | |
|
| ||
| Phospholipid metabolism | EFV56439 | phospholipase, patatin family |
| EFV60905 | phospholipase D3 protein | |
|
| ||
| Epigenetic process regulatory machinery | EFV58204 | putative CXXC zinc finger domain protein |