Table 2.
The inhibitory effects of magnolol on different targets.
| Substrate | Enzyme (target) source | IC50 (μM) | Ki (μM) | EC50 (μM) | Ref. |
|---|---|---|---|---|---|
| NF | CYP1A | 1.62 | 1.09-12.0 | - | [20] |
| SPZ | CYP2C | 0.56 | 10.0-15.2 | - | |
| KCZ | CYP3A | 35 | 93.7-183 | - | |
|
| |||||
| meropenem | NDM-1 | 6.47 (μg/mL) | - | - | [60] |
|
| |||||
| - | Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans | 100 | - | - | [61] |
|
| |||||
| CP55,940 | CB2 | - | 1.44 | 3.28 | [25] |
|
| |||||
| pNP-α-G | α-Glucosidase | 2.0 | - | - | [62] |
|
| |||||
| 4-hydroxy tolbutamide | CYP2C | 41.48 | - | - | [21] |
| dextrorphan | CYP2D6 | 65.42 | |||
| 6-hydroxy chlorzoxazone | CYP2E1 | 67.93 | |||
| 6-hydroxy testosterone | CYP3A4 | 52.36 | |||
| hydroxybupropion | CYP2B6 | 28.69 | |||
|
| |||||
| p-NPP | PTP1B | 24.6 | - | - | [63] |
|
| |||||
| - | PPARγ (agonist) | - | 2.04 | 1.6 | [64] |
|
| |||||
| β-Estradiol | UGT1A1 | 36.8 | - | - | [28] |
| β-Estradiol | Hela1A1 | 22.6 | - | - | |
| SN-38 | UGT1A1 | 13.2 | - | - | |
| SN-38 | Hela1A1 | 16.4 | - | - | |
|
| |||||
| 4-Mu | UGT1A7 | - | 0.487 | - | [29] |
| 4-Mu | UGT1A9 | - | 0.048 | - | |