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. Author manuscript; available in PMC: 2020 May 15.
Published in final edited form as: J Am Chem Soc. 2019 May 3;141(19):7698–7703. doi: 10.1021/jacs.9b02611

Figure 1.

Figure 1.

GECCO to site-selectively introduce biochemically reactive amino acids into proteins. The latent bioreactive Uaa FSY reacts with a nearby Ser or Thr via proximity-enabled reactivity, selectively converting the latter into Dha or Dhb.