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. Author manuscript; available in PMC: 2019 Jun 9.
Published in final edited form as: Nature. 2018 Sep 10;561(7723):411–415. doi: 10.1038/s41586-018-0518-z

Figure 4 |.

Figure 4 |

Identification of dynamic protein clusters. (a) SURF interest points were detected and assigned to one of 100 clusters of similar interest points. Non-negative factorization of the data tensor of 28 proteins × features × mitotic stages produced a non-negative tensor of reduced dimension whose entries can be interpreted as the fraction of protein belonging to each cluster over time (right panel, each cluster is represented by a different colour and the height of a coloured bar at a given mitotic stage represents the fraction of the protein in the corresponding cluster at this stage). Scale bar: 10 μm. (b) Dynamic multi-graph of protein co-localization, shown for 5 stages. Each edge colour corresponds to a localization cluster as in (a) and the edge thickness corresponds to the product of the linked genes fractions in the corresponding cluster and can be loosely interpreted as a probability of interactions.