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. Author manuscript; available in PMC: 2020 Feb 6.
Published in final edited form as: J Am Chem Soc. 2019 Jan 24;141(5):1961–1969. doi: 10.1021/jacs.8b10521

Figure 3.

Figure 3.

Models of (A) EryAT6 Y744R and (B) PikAT6 Y753R ATs after undergoing MD simulations. Distances between catalytic residues in the mutant EryAT6 (4.8 Å) are long but catalytically-competent. The same distance in the mutant PikAT6 (8.4 Å) is characteristic of an inactive AT domain.