Table 1.
Compound | Target | EC50 (uM) | CC50 (uM) | SI (CC50/EC50) | Ref. |
---|---|---|---|---|---|
Catechin | Host Cell GAGs | 36.50 ± 8.40 | 124.33 ± 33.53 | 3 | [54, 63] |
Quercetin | Host Cell GAGs | 191.68 ± 24.25 | 670.02 ± 180.18 | 3 | [54, 63] |
3,4,5-Trimethoxybenzoic acid | Host Cell GAGs | 2142.74 ± 266.37 | >5042.41 | 2 | [54, 63] |
Trimethoxyacetophenone | Host Cell GAGs | 1023.98 ± 64.62 | 3738.98 ± 1099.17 | 3 | [54, 63] |
3,4,5-Trimethoxybenzoic acid ethyl ester | Host Cell GAGs | 822.23 ± 134.38 | 3204.20 ± 397.87 | 3 | [54, 63] |
Butyl gallate | Host Cell GAGs | 109.79 | 113.23 ± 52.35 | 1 | [54, 63] |
PAV-866 | ABCE1 | ~0.15–0.30 | ~2.5–10 | ~100 | [55] |
Sorafenib | Tyrosine Kinases | 1.463 | >160 | 109 | [22] |
2-piperidin-3-yl-benzothiazole analog | Nedd4 | 0.345 | >1 | >3 | [126] |
1-acetyl-3-(2,2,2-trifluoroethyl)-urea analog | Nedd4 | 0.210 | >1 | >8 | [126] |