Scheme 8.
Reagents and conditions: a. (i) EtMgBr, THF, −78 °C, (ii) ZnCl2, 2 h, rt; b. 14, Pd(PPh3)4, CuI, THF, rt, 18 h; c. acetic acid, rt, 18 h; d. TFA, rt, 18 h; e. BBr3, EtOAc, rt, 72 h.
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