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. 2019 May 15;27(13):2883–2892. doi: 10.1016/j.bmc.2019.05.019

Scheme 11.

Scheme 11

Reagents and conditions: a. bis(tributyltin), Pd(PPh3)2Cl2, 1,4-dioxane, 120 °C, 18 h; b. BBr3, CH2Cl2, rt, 48 h; c. NH3, CH3OH, 120 °C, 72 h; d. POCl3, reflux, 18 h; e. ADA.