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. 2019 May 15;27(13):2883–2892. doi: 10.1016/j.bmc.2019.05.019

Scheme 14.

Scheme 14

Reagents and conditions: a. (i) EtMgBr, THF, −78 °C, (ii) ZnCl2, 2 h, rt, (iii) 32, Pd(PPh3)4, CuI, THF, rt and reflux, 18 h.