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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Dec 12;4(6):533–542. doi: 10.1016/j.bpsc.2018.12.002

Figure 1. MRI-compatible headpost assembly and image quality across modalities.

Figure 1.

A. Schematics of the borosilicate glass window implant.

B. Schematic illustration of the window implant over the whisker representation within the primary somatosensory cortex (SI) and the headpost fixed to the skull overlaying the other (contralateral) hemisphere.

C. Images of the brain vasculature through the glass window implant obtained by 2-photon imaging of fluorescein isothiocyanate (FITC)-labeled dextran injected intravenously. The images illustrate preserved integrity of the vasculature between days 1 (top) and 28 (bottom) following surgical implantation.

D) Two-photon image stack obtained with Alexa 680 labeled dextran injected intravenously illustrating the capability of deep imaging.

E) Corrected GE EPI image (left) and a corresponding structural image (TurboRARE, right). Red arrows point to the peripheral edges of the implant, i.e., the glass/bone boundary. The red line indicates the bottom of the glass implant, i.e., the glass/brain boundary.