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. 2019 Jun 5;12:4427–4435. doi: 10.2147/OTT.S201728

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© 2019 Hao et al.

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LCA inhibited IGF-1-induced cell viability, migration, and invasion by regulating the PI3K/AKT pathway. Cells were stimulated with 100 ng/mL of IGF-1 for 20 minutes and then treated with 100 μM LCA for 24 hours. (A and B) The effect of LCA on IGF-1-mediated PI3K/AKT pathway was investigated in SCC4 and CAL-27 cells. (C and D) The expression of PCNA protein was detected in SCC4 and CAL-27 cells after IGF-1 and LCA treatment. (E and F) The number of migration cells was analyzed in SCC4 and CAL-27 cells. (G and H) The ability of invasion was investigated in cells with IGF-1 and LCA exposure. *P<0.05.

Abbreviations: LCA, Licochalcone A; PCNA, proliferating cell nuclear antigen.