Figure 2.

Effects of celecoxib, indomethacin and ibuprofen (2.5 and 5 μM) on intracellular (A) reactive oxygen species (ROS) and (B) glutathione (GSH) in nerve growth factor (NGF)-differentiated PC12 cells induced by 6-hydroxydopamine (6-OHDA). (A) All three compounds (celecoxib, indomethacin and ibuprofen) could prevent 6-OHDA-induced ROS increment. (B) All three compounds could prevent 6-OHDA-induced GSH reduction. Values are the mean ± SD. *P< 0.05, **P< 0.01 and ***P< 0.001 compared to 6-OHDA group. All experiments were performed in triplicate ((A) at least 3 independent experiments into each of four wells of a 96-well plate, (B) at least 3 independent experiments into each of three wells of a 6-well plate)