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. 2019 May;22(5):477–484. doi: 10.22038/IJBMS.2019.34011.8091

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of celecoxib, indomethacin and ibuprofen (2.5 and 5 μM) on apoptosis by flowcytometry with propidium iodide (PI) in nerve growth factor (NGF)-differentiated PC12 induced by 6-hydroxydopamine (6- OHDA). (A) and (B) pretreatment of the cell with celecoxib, indomethacin and ibuprofen significantly prevented 6-OHDA-induced apoptosis. Values are the mean±SD. *P<0.05, **P<0.01 and ***P<0.001 compared to 6-OHDA group. All experiments were performed in triplicate (at least 3 independent experiments into each of three wells of a 12-well plate)