Fig. 6.

Extracting a high-dimensional imaging “fingerprint”. The T1-weighted MRI volume is used to obtain the regional parcellation of the brain, and alongside the FLAIR to detect white matter lesions. The brain “disconnectome”, which is subsequently obtained using the detected lesion mask, is a probabilistic map of regional disconnection. The degree of disconnection is colour coded, so that grey matter regions that appear more yellow in the disconnectome map are predicted to have higher degrees of disconnection, due to the presence of the multiple sclerosis lesions in the white matter tracts that are connected to them, than regions which appear in red. The output from all these steps, following slope and trajectory calculation, is a high-dimensional imaging “fingerprint” comprising the trajectories of the normalised regional brain volumes and the degrees of disconnection for each of the regions in the brain parcellation