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. 2019 Jun 10;15(6):89. doi: 10.1007/s11306-019-1548-8

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — Metabolomics and histological analysis of liver and metabolomics analysis of spleen and kidney. a Liver histology, type 2 diabetes individuals showed clear fat accumulation characteristic of steatosis (lower row) compared to control liver (top row) in all the liver lobes. b PCA showing clusters control and diabetic individuals respectively. Higher variability was observed in healthy individuals. c O-PLS DA model calculated using all liver spectra as a matrix of independent values (R²Y = 0.83 and Q²Y = 0.71). d spleen O-PLS DA model calculated using all spectra as a matrix (n = 12) of independent variables and genetic background as predictor (R²Y = 0.85, Q²Y = 0.67, n = 12). e Kidney O-PLS DA model calculated using all spectra as a matrix (n = 12) of independent variables and genetic background as predictor (R²Y = 0.95, Q²Y = 0.91)