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Observed (markers) and model prediction (lines) of THC concentration–time profiles in the (A) absence and (B) presence of sulfaphenazole, 11-OH-THC formation in the (C) absence, and (D) presence of sulfaphenazole, 11-OH-THC depletion by P450 enzymes in the (E) absence and presence of (F) sulfaphenazole and (G) itraconazole, (H) 11-OH-THC depletion by UGT enzymes, and (I) COOH-THC formation in the absence of inhibitors. Additional goodness-of-fit graphs are shown in Supplemental Fig. 3.
