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. 2019 May 16;26:101220. doi: 10.1016/j.redox.2019.101220

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 8 — Sodium sulfide selectively radiosensitizes GBM to ionizing radiation. T98G cells were treated with 476 μM Na₂S or degassed water for a total of 4 h and irradiated during the 4^th hr of Na₂S treatment. Surviving fraction at each radiation dose was normalized to their respective controls to account for Na₂S induced killing (A). Data were curve fit to the linear quadratic (LQ) equation to calculate RBE₁₀ and DEF₁₀ at 10% surviving fraction (SF₁₀). Protons had an RBE₁₀ = 1.2. Photons and protons had a DEF₁₀ = 1.34. hCMEC/D3 cells were similarly irradiated using a clinically relevant dose of 2 Gy (B) and data analyzed by two-way ANOVA with Tukey's post-hoc for multiple comparison.