Fig. 2.

SAXS. X-ray scattering curves and the dimensionless Kratky plot (ScÅtter) for ApoE2 (a), ApoE3 (b) and ApoE4 (c) are shown, as well as their corresponding pair distance distribution function (d) P(r). (a–c) All ApoE isoforms have identical scattering profiles and adopt an extended conformation in solution with some intrinsic level of flexibility as assessed by the dimensionless Kratky plot. (d) This extended conformation is seen in the P(r) distribution, respectively, and a maximal dimension D_max of approximately 19.5 nm (195 Å) is determined for each isoform.