Table 3.
Secondary structure analysis of recombinant ApoE isoforms from CD spectroscopy dataa
| α-Helix (%) | β-Strand (%) | β-Turn (%) | Random coil (%) | NRMSD (%) | |
|---|---|---|---|---|---|
| ApoE2 | 57.3 | 3.5 | 14.1 | 25.3 | 0.0178 |
| ApoE3 | 59.5 | 3.3 | 13.0 | 24.2 | 0.0190 |
| ApoE4 | 58.4 | 3.4 | 13.5 | 24.7 | 0.0184 |
The normalized root mean square deviation (NRMSD) is an estimate of the goodness-of-fit (NRMSD < 0.1 is a necessary but not sufficient condition.
α-helical content was similar between the three ApoE isoforms (within experimental error).
a
Calculated by CONTIN program at DichroWeb (http://dichroweb.cryst.bbk.ac.uk/html/home.shtml).