Figure 4.

HPK1–sunitinib and comparable domain-swapped dimers from the PDB. A, the HPK1^2PM KD in a domain-swapped dimer. Chain A is shown as a green cartoon with transparent surface, and chain B is shown as a cyan cartoon. Inhibitor and WYMAPE residues are drawn as sticks. The active-site surface is colored yellow in subunit A. B, zoomed-in view of HPK1^2PM domain swap. Selected chain A side chains (green) surrounding YWMAPE residues from the P + 1 and APE motifs of chain B (cyan) are shown. C, equivalent view of HPK1^+0P chain A (dark green) to illustrate the duplication of interactions in domain-swapped and nonswapped dimers. D, crystal structures of selected kinase domains from the PDB that assemble as domain-swapped dimers.