Figure 1.

Drug screening identified four chemicals enhancing cardiac reprogramming. A, schematic diagram of the chemical screening using α-MHC–GFP MEFs. B, bar graph showing % α-MHC–GFP+ cells 2 weeks after GMT infection with or without indicated chemical treatment. C, representative FACS plots showing iCMs with α-MHC–GFP+ cells after 2 weeks of reprogramming and quantification. D, bar graph representing major cardiac and fibroblast genes as determined by qPCR. Error bars indicate mean ± S.E.; *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001 compared with MGT+DMSO group.