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. 2019 May 1;9(5):927–944.

Figure 6.

Figure 6

Phosphorylated AKT is required for the miR-873-induced metabolic shift. A. Western blot assays show that miR-873 increases AKT and S6K phosphorylation but does not affect total AKT, c-Myc, or HIF1α expression. B. Western blot assays show that block of AKT phosphorylation with LY294002 blocks miR-873-induced upregulation of HK2 and Glut1 in SMMC-7721 cells. C. Block of AKT phosphorylation with LY294002 decreases miR-873-induced increases in lactate secretion in SMMC-7721 cells. D. Block of AKT phosphorylation with LY294002 decreases miR-873-induced increases in the rate of glucose uptake in SMMC-7721 cells. *P < 0.05 and **P < 0.01, #represents not statistically significant.