Figure 5.
FAT4 inhibited EC carcinogenicity in vivo. A: HEC-1B cells were tranfected with either NC or shFAT4 and injected into BALB/c nude mice subcutaneously (0.2 mL, 1 × 106 cells). Tumor size and weight were monitored every 3 days. Silenced FAT4 significantly promoted EC tumor growth, the data are mean ± SD, *P<0.05, t test. C: RL95-2 cells were tranfected with either NC or sgRNA2 and injected into BALB/c nude mice subcutaneously (0.2 mL, 1 × 106 cells). Tumor size and weight were monitored every 3 days. Upregulated FAT4 significantly inhibited EC tumor growth, the data are mean ± SD, *P<0.05, t test. B and D: IHC staining for FAT4 and Ki67 in sections of transplanted tumors. *P<0.05, t test. Person’s correlation.